Prof. Zhi-rong Zhang’s group published new data on renal drug delivery
Prof. Zhi-rong Zhang, dean of the West China School of Pharmacy and professor in pharmaceutics, recently reported their research on renal drug delivery in Biomaterials, which is one of the best journals in its field and a peer-reviewed forum for the publication of original papers and authoritative review papers dealing with the most important issues facing the use of materials in clinical practice.
The research titled as “The targeting of 14-succinate triptolide-lysozyme conjugate to proximal renal tubular epithelial cells” was published” in Biomaterial on September 18, 2008. The study focused on an immunosuppressant conjugate for renal specific delivery especially for proximal tubular epithelial cells (PTEC) targeting though megalin receptor. PTEC, which exist in the renal cortex, not only constitute one of the major victims of the alloimmune response but also act as a trouble maker, a suitable target site for local immunosuppressants to the kidney. Their data demonstrated the efficacy and safety of this PTEC specific triptolide therapeutics as well as its potential clinical applications as a local immunosuppressant. The concentration of the conjugate in kidney quickly reached more than twenty times higher than free drug 30 minutes after injection into mice.
The novelty and significance were highly appreciated by the editors and they pointed out “a full spectrum of research has been conducted from synthesis and characterization, in vitro cellular uptake and cytotoxicity, to in vivo pharmacokinetics and biodistribution, which showed the proof-of-concept experimental results. This is an excellent work in a branch of nanomedicine - bioconjugates for targeted drug delivery.”