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Ling Wang

Personal Details

First Name: Ling     Last Name: Wang
Gender: Female
Degree: Ph.D.
Tel: 86-28-85503968
Email: rebeccawang312@gmail.com
 

Education

09/2003- 06/2006
West China School of Pharmacy, Sichuan University, Sichuan, P. R. China
Major: Biopharmaceutics and Pharmacokinetics   
Degree: Ph. D
09/2000- 06/2003
 
West China School of Pharmacy, Sichuan University, Sichuan, P. R. China
Major: Pharmaceutical Sciences                  
Degree: M. S
09/1996 – 06/2000
West China School of Pharmacy, Sichuan University, Sichuan, P. R. China
Major: Pharmacy                              
Degree: B. S
 

Knowledge Background

Pharmacokinetics research on Traditional Chinese Medicine compounds, extracts and preparations
Pharmacogenetic research on metabolic enzymes and transporters and their impacts on therapeutic medications
Skills of Clinical Pharmacokinetics and Bioavailability and Bioequivalence Trials
Experience on Pre-Clinical Pharmacokinetics Experiments
Designation of formulation and preparation of Dosage forms
 

Research Experience  

10/2008-present West China School of Pharmacy, Sichuan University
I am responsible for the clinical pharmacokinetic study including study design, monitoring clinical study, sample assay, data analysis and report drafting.  
 
05/2010-09/2011 The new drug application reviewer, State Food and Drug Administration of China
Reviewed the clinical pharmacokinetic studies for new drug application.
 
02/2008-10/2008 Research assistant in the Chinese University of Hong Kong
Worked as a research staff in a project titled with “A Bio-activity Guided in Vitro Pharmacokinetic Method to Improve the Quality Control of Chinese Medicines” founded by Innovation and Technology Fund of Hong Kong. The major responsibility was to identify the bio-active marker(s) for quality control of Chinese medicine formulae.
 
07/2006-02/2008 Post doctoral training in Sichuan University
Responsible for project “the elementary research of the interaction of Bisbenzylisoquinoline (BBIQ) with chemotherapeutics” as part of “the research of the role and regulation of P-glycoprotein in absorptive process of orally administered traditional Chinese medicine” funded by the National Nature Science Foundation of China.
 
09/2003-06/2006  Ph.D thesis research work
Study on absorption mechanism and method of enhance absorption of lipophilic components of Danshen (funded by the National Nature Science Foundation of China) as my PhD research.
As primary investigator, having accomplished the human bioequivalence or clinical pharmacokinetics trials of nearly ten new products cooperated with pharmaceutical companies.
 
09/2000-07/2003 M. Sc degree thesis research work
Research of the purification and preparation of Danshen (a widely-applied “Blood invigorating” in TCM) injection. Also I had completed several products R&D (mainly about the formulation and preparation of the new drugs.) such as palmatine sustained-release capsule, kakkonein-loaded solid lipid nanoparticles, andrographolide transfusion, polyactin chewable tablet and dextromethorphan hydrobromide tablet cooperation with pharmaceuticals companies.
 

Other related teaching experience and trainings

Training Experience
02/2008-05/2008: Mass Spectrometry Instrumentation, Hong Kong Society of Mass Spectrometry
07/2005: Application of LC/MS/MS into pre-clinical and clinical pharmacokinetics trials.
11/2003 to 01/2004: Cell culture technique model (Caco-2, MDCK, HEK293 and MCF-7 cells) at the National Key Laboratory of Tissue Engineering, Sichuan University;
09/2004. GCP (Good Clinical Practice) training by Drug Clinical Trail Center of SFDA;
09/2003-11/2003: The certificate of animal experiment awarded by the Institutional Animal Care and Use Committee of Sichuan University;
12/2002-09/2003: Training of Clinical Pharmacist in University hospitals with good results.
Teaching Experience
09/2008 to present: Teaching “General concept of Pharmaceutics” for undergraduate students. West China School of Pharmacy, Sichuan University;
05/2007 to 07/2007: Teaching “New technique and New Method in drug discovery” for graduate students. West China School of Pharmacy, Sichuan University;
09/2006 to 11/2006: Teaching “Modern Evaluation Method for New Drug” for graduate students. West China School of Pharmacy, Sichuan University;
02/2004 to 06/2004: Teaching “biopharmaceutics and pharmacokinetics” for undergraduate students. West China School of Pharmacy, Sichuan University;
03/2002 to 07/2002: Teaching Assistant, Department of Pharmaceutics, West China School of Pharmacy, Sichuan University;
 

Publications, Patents and Books

Publications:
· Xu Chen, Wensheng Zhang, Sandy Rios, Miriam B Morkos, Xiaoli Ye, Gen Li, Xuehua Jiang, Zhijun Wang, Ling Wang. An HPLC tandem mass spectrometry for quantification of ET-26-HCl and its major metabolite in plasma and application to a pharmacokinetic study in rats. Journal of Pharmaceutical and Biomedical Analysis 2017
· Ting Wang, Fangyi Long, Xiqian Zhang, Yujie Yang, Xuehua Jiang, Ling Wang. Chemopreventive effects of atractylenolide II on mammary tumorigenesis via activating Nrf2-ARE pathway. Oncotarget 2017,8(44):77500
· Wei Xiong, Jiajia Zhao, Ling Wang, Xuehua Jiang. UPLC‐MS/MS method for the determination of tobacco‐specific biomarker NNAL, tamoxifen and its main metabolites in rat plasma. Biomedical Chromatography 2017,31(6)
· Tingting Li, Ah-Ng Tony Kong, Zhiqiang Ma, Haiyan Liu, Pinghua Liu, Yu Xiao, Xuehua Jiang, Ling Wang. Protein arginine methyltransferase 1 may be involved in pregnane x receptor-activated overexpression of multidrug resistance 1 gene during acquired multidrug resistant. Oncotarget 2016,7(15):20236
· Ting Wang, Leting Yang, Jing Hua, Huiru Xie, Xuehua Jiang, Ling Wang. Simultaneous bioanalysis of rasagiline and its major metabolites in human plasma by LC–MS/MS: Application to a clinical pharmacokinetic study. Journal of pharmaceutical and biomedical analysis 2016,125:280-5
· Yu Xiao, Gang Hu, Dandan Dong, Wei Tian, Tingting Li, Xuehua Jiang, Ling Wang. Prognostic value of NRF2 in breast cancer patients and its role as a tumor suppressor by directly inhibiting HER2 expression. INTERNATIONAL JOURNAL OF CLINICAL AND EXPERIMENTAL PATHOLOGY 2016,9(4):4292-306
· Yujie Yang, Qiang Cheng, Xiumei Liu, Zejuan Liu, Tingting Li, Xuehua Jiang, Ling Wang. Comparisons of pharmacokinetics and NO‐releasing of nitrofibriate and fenofibrate after oral administration in rats. Biomedical Chromatography 2016,30(12):2003-8.
· Xiqian Zhang, Rujun Ma, Xiaojuan Liu, Xuehua Jiang, Ling Wang. Simultaneous determination of ginsenoside Rg1, Re and notoginsenoside R1 in human plasma by LC‐MS/MS and its application in a pharmacokinetic study in Chinese volunteers. Biomedical Chromatography 2016,30(12):1915-21
· Xiaodan He, Li Li, Hong Su, Dinglun Zhou, Hongmei Song, Ling Wang, Xuehua Jiang. Poly (ethylene glycol)-block-poly (ε-caprolactone)–and phospholipid-based stealth nanoparticles with enhanced therapeutic efficacy on murine breast cancer by improved intracellular drug delivery. International journal of nanomedicine 2015,10:1791
· Tingting Li, Zhijun Wang, Haiyan Liu, Huiru Xie, Xuehua Jiang, Ling Wang. Reversal of multidrug resistance in cancer treatment by regulating multidrug resistance gene1: focus on nuclear receptors and epigenetics. J Chin Pharm Sci 2015,24(5):273-84
· Ting Wang, Aidong Wen, Zhijun Wang, Lin Yang, Huiru Xie, Xuehua Jiang, Ling Wang. Pharmacokinetic Properties of Allantoin and the Effect of Food in Chinese Volunteers. LATIN AMERICAN JOURNAL OF PHARMACY 2015,34(7):1343-9.
· Ting Wang, Huiru Xie, Xu Chen, Xuehua Jiang, Ling Wang. Simultaneous determination of leucine, isoleucine and valine in Beagle dog plasma by HPLC–MS/MS and its application to a pharmacokinetic study. Journal of pharmaceutical and biomedical analysis 2015,114:426-32
· Ting Wang, Kun Zhang, Tingting Li, Lin He, Huiru Xie, Xuehua Jiang, Ling Wang. Prevalence of Desloratadine Slow-metabolizer Phenotype and Food-dependent Pharmacokinetics of Desloratadine in Healthy Chinese Volunteers. Clinical drug investigation 2015,35(12):807-13
· Qingqing Du, Ting Wang, Zhijun Wang, Xuehua Jiang, Ling Wang. Rapid Determination of Glutamine in Human Plasma by High-Performance Liquid Chromatographic–Tandem Mass Spectrometry and Its Application in Pharmacokinetic Studies. Journal of chromatographic science 2014,53(1):79-84
· Lin Song, Qingqing Du, Xuehua Jiang, Ling Wang. Effect of CYP1A2 polymorphism on the pharmacokinetics of agomelatine in Chinese healthy male volunteers. Journal of clinical pharmacy and therapeutics 2014,39(2):204-9
· Ling Wang, Chengyue Zhang, Yue Guo, Zheng-Yuan Su, Yuqing Yang, Limin Shu, et al. Blocking of JB6 cell transformation by tanshinone IIA: epigenetic reactivation of Nrf2 antioxidative stress pathway. The AAPS journal 2014,16(6):1214-25
· Huiru Xie, Zhijun Wang, Ke Deng, Xuehua Jiang, Ling Wang, Guoyu Lv. An HPLC–MS/MS method for simultaneous determination of the active metabolites of febuxostat (67M-1, 67M-2 and 67M-4) in human plasma. Journal of Chromatography B 2014,970:24-30
· Qing-qing Du, Zhi-jun Wang, Lin He, Xue-hua Jiang, Ling Wang. PXR polymorphisms and their impact on pharmacokinetics/pharmacodynamics of repaglinide in healthy Chinese volunteers. European journal of clinical pharmacology 2013,69(11):1917-25
· Yanran Wang, Zhaohui Jin, Zhijun Wang, Xuehua Jiang, Ling Wang. Pharmacokinetic properties of isradipine after singledose and multipledose oral administration in Chinese volunteers: a randomized, openlabel, parallelgroup phase I study. Biomedical Chromatography 2013,27(12):1664-70
· Ling Wang, Lin Song, Xuehua Jiang. Quantification of sofalcone in human plasma and urine by high performance liquid chromatography-mass spectrometry. Journal of Pharmaceutical and Biomedical Analysis 2011,55(5): 1179-1185
· Lin Song, Xuehua Jiang, Ling Wang. Determination of butenafine hydrochloride in human plasma by liquid chromatography electrospray ionization-mass spectrometry following its topical administration in human subjects. Journal of Chromatography B 2011, 879 (30): 3658-3662
· Ling Wang, Zhijun Wang, Siukwan Wo, Clara B.S. Lau, Xiao Chen, Min Huang, Vincent H.L. Lee, Moses S.S. Chow, Zhong Zuo. A bio-activity guided in vitro pharmacokinetic method to improve the quality control of Chinese medicines, application to Si Wu Tang. International Journal of Pharmaceutics 2011, 406(1-2): 99-105.
· Ying Zhang, Ling Wang, Han Zhang, Xuehua Jiang, Qingqing Du. Determination of Tetrandrine in Rat Whole Blood by RP-LC and Its Application to Pharmacokinetic Studies. Chromatographia 2011, 73:1097-1103
· Zhijun Wang, Siukwan Wo, Ling Wang, Clara B.S. Lau, Vincent H.L. Lee, Moses S.S. Chow, Zhong Zuo. Simultaneous quantification of active components in the herbs and products of Si-Wu-Tang by high performance liquid chromatography-mass spectrometry. Journal of Pharmaceutical and Biomedical Analysis 2009, 50(2):232-244
· Ruoqi Zhang, Xuehua Jiang, Ling Wang. Pharmacokinetics and Tolerability of Multiple-Dose Rosuvastatin: An Open-Label, Randomized-Sequence, Three-Way Crossover Trial in Healthy Chinese Volunteers. Current Therapeutic Research(Clinical and Experimental) 2009, 70(5): 392-404
· Ling Wang, Jiang Xuehua, Xu Weijuan, Li Chenrui. Complexation of Tanshinone II A with 2-Hydroxypropyl-β-Cyclodextrin: Effect on Aqueous Solubility, Dissolution Rate, and Intestinal Absorption Behavior in Rats. International Journal of Pharmaceutics 2007, 341(1-2): 58-67
· Ling Wang, Chenrui Li, Xuehua Jiang. In Situ Intestinal Absorption Behaviors of Tanshinone IIA from its Inclusion Complex with Hydroxypropyl-β-Cyclodextrin. Biological & Pharmaceutical Bulletin 2007, 30 (10):1918-1922
· Jing Ren, Xue-Hua Jiang, Kejia Li, Chuanchuan Zhang, Chenrui Li, Ling Wang. Bioequivalence of Two Formulations of a Single Oral Dose of 500-mg Azithromycin Granules: A Randomized, Open-Label, Two-Period Crossover Study in Healthy Han Chinese Volunteers. Current Therapeutic Research 2007, 68(35): 369-377
· Ke Lan, Xuehua Jiang, Yunxia Li, Ling Wang, Jing Zhou, Qian Jiang, Limin Ye. Quantitative determination of rosuvastatin in human plasma by ion pair liquid–liquid extraction using liquid chromatography with electrospray ionization tandem mass spectrometry. Journal of Pharmaceutical and Biomedical Analysis 2007, 44(2): 540-546
· Ke Lan, Jian-lin He, Yang Tian, Fei Tan, Xue-hua Jiang, Ling Wang, Li-ming Ye. Intra-herb pharmacokinetics interaction between quercetin and isorhamentin. Acta Pharmacologica Sinica 2008, 29 (11): 1376-1382
 
Patent:
· A device for animal exposing with mainstream smoke of cigarette. China Patent # ZL2016202779024.4, 2016. Ling Wang, Jiajia Zhao, Wei Xiong, Xuehua Jiang. 
· A new method for preparing the compound extract containing Dandelion and its new application. China Patent # ZL200910263536.1, 2010. Ling Wang, Xuehua Jiang, Pingping Song. 
 
Book Chapters:
& Biopharmaceutics and Pharmacokinetics Science Press 2017 (First Edition)
& Biopharmaceutics and Pharmacokinetics China Medical Science Press 2016  
     (First Edition)
& Drug Design Higher Education Press 2015 (First Edition) 
& Introduction to clinical pharmacy People’s Medical Publishing House 2014
    Second Edition
& Introduction to Pharmacy Tsinghua University Press 2013 (First Edition) 
& Aduanced Methods of Pharmaceutical Evaluation People’s Medical Publishing
     House 2008 (First Edition)
& Guidance of Clinical Pharmacy People’s Medical Publishing House 2007 (First
     Edition)
& Clinical Pharmacokinetics Higher Education Press 2007 (First Edition)
 

Awards & Honors

June 2016
The Award of Excellent school materials of Sichuan University for 2015-2016 academic year
May 2015
The Award Program for Young-backbone teachers of 2014 of Sichuan University
October 2012
Second-class Prize Winner of the teaching achievement prize of 2012 of Sichuan University
December 2008
Second-class Prize Winner of Education and teaching achievements of 2008 of Sichuan University
December 2008
Third-class Prize Winner of science and technology progress in Sichuan of 2008
October 2007
Excellent doctoral dissertation of 2006 of Sichuan University 
March 2005
Third-class Prize Winner of ‘Excellent Postgraduate Student Scholarship’ for 2004-2005 academic year
October 2003
First-class Prize Winner of ‘Excellent Postgraduate Student Scholarship’ for 2002-2003 academic year
October 1999
Second-class Prize Winner of ‘Excellent Postgraduate Student Scholarship’ for 1998-1999 academic year
MAIL to Prescent
Main campus address:
Wangjiang campus: section of Chengdu No. 24 Southern Yihuan Code: 610065 | 29 Jiuyanqiao WangjiangRoad, Chengdu Zip: 610064
Huaxi Campus: Chengdu, People’s SouthRoad was on the 17th Zip: 610041
Jiang’an Campus: Shuangliu County, Chengdu, Sichuan road Zip: 610207
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