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RONG YU
Profossor RONG YU (Ph.D)
Recent research interests
I am mainly engaged in the structure, function and drug discovery studies from nature macromolecule and biopharmaceuticals manufactured by biotechnology methods.
1. DNA recombinant medicine
This study relates to the development of various recombinant DNA technology and high performance purification scheme for biopharmaceuticals. These projects usually involve construction, expression and purification of novel recombinant medicine. The gene recombinant separation technique makes a key success in modern biopharmaceutical. The techniques of separation and purification these proteins take important position in gene engineering.
2. Biochemical medicine and Microbial medicine 
The objective of this project is to develop fast and efficient large scale biochemical isolation technology that will enable a high recovery of products. Process integration will be performed by combination of cell disruption, membrane separation and various chromatography.
3.The protein engineering therapeutics design
This research is aimed to develop new biotech drugs. The protein engineering technique has become an effective stratagem to improve variant properties of therapeutic proteins, including enhanced thermo stability, bioactive specify, targeted delivery, decrease in immunity and improving pharmacokinetics. Rational protein engineering is according to the hypothesis driven manipulation of protein sequence and/or composition. Biopharmaceuticals are now entering the third stage of product development in which true lead optimization to modulate the physical, chemical and biological properties of proteins is possible. Rational optimization of proteins as drugs makes a key success in modern biopharmaceutical. The controlled manipulation of the physical, chemical and biological properties of proteins enabled by structure-based simulation is now being used to refine established rational engineering approaches and to advance new strategies. These methods provide clear, hypothesis driven routes to solve problems that plague many proteins and to create novel mechanisms of action. An increasing number of engineered protein therapeutics are currently being developed, tested in clinical trials and marketed for use.
 
Main Publications
(1) Yaqiong LiXiunan Li (*) Chao ChenDawei ZhaoZhiguo SuGuanghui, MaRong Yu (*) , Sol–gel transition characterization of thermosensitive hydrogels based on water mobility variation provided by low field NMRJournal of Polymer Research2017.2.242425
(2)Li YaqiongLi Xiunan (*)Chen ChaoZhao DaweiSu ZhiguoMa GuanghuiYu Rong(*) , A rapid, non-invasive and non-destructive method for studying swelling behavior and microstructure variations of hydrogelsCarbohyd rate Polymers2016.10.201511251~1260
(3) Cai YingtingBao JingxiaoLao Xingzhen(*) Zheng HengChen JianhuaYu Rong(*), Computational design, functional analysis and antigenic epitope estimation of a novel hybrid of 12 peptides of hirudin and reteplaseJournal of Molecular Modeling2015.9.01219
(4) Zhang ChunLiu Yongdong(*)Zhao DaweiLi Xiunan, Yu Rong(*) ,Su Zhiguo, Facile purification of Escherichia coli expressed tag-free recombinant human tumor necrosis factor alpha from supernatantProtein Expression and Purification2014.3.0195195~203
(5) Gao LingZhang ChunLi LinglingLiang LanDeng XuanWu WutongSu ZhiguoYu Rong(*), Construction, Expression and Refolding of a Bifunctional Fusion Protein Consisting of C-Terminal 12-Residue of Hirudin-PA and ReteplaseProtein Journal2012.4.01314):328~336
(6)Xiang SilongMa Yuyuan(*) Yan QipoLv MaominZhao XiongYin HuiqiongZhang NianJia JuntingYu Rong(*)Zhang, JingangCo nstruction and characterization of an infectious replication competent clone of porcine endogenous retrovirus from Chinese miniature pigsVirology Journal2013.7.910
7 ShuangYinChun Zhang ZenglanLi ..QiWang HongShiRongYuYongdongLiuZhiguoSu
8.Zhang Chun, Yu Rong ZenglanLi, CuiFeng, Qi Wang,Yongdong Liu, Zhiguo Su Development of long-acting ciliary neurotrophic factor by site-specific conjugation with different-sized polyethylene glycols and transferrin  International Journal of Pharmaceutics 2017, 529(1–2), 275-284
MAIL to Prescent
Main campus address:
Wangjiang campus: section of Chengdu No. 24 Southern Yihuan Code: 610065 | 29 Jiuyanqiao WangjiangRoad, Chengdu Zip: 610064
Huaxi Campus: Chengdu, People’s SouthRoad was on the 17th Zip: 610041
Jiang’an Campus: Shuangliu County, Chengdu, Sichuan road Zip: 610207
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